Analgesic effect of continuous femoral nerve block combined with infiltration anesthesia after total knee replacement

摘要

Objective:To study the analgesic effect of continuous femoral nerve block combined with infiltration anesthesia after total knee replacement.Methods:Patients who received unilateral total knee replacement in our hospital from May 2012 to August 2015 were included for study and randomly divided into experimental group who received continuous femoral nerve block combined with infiltration anesthesia and control group who received continuous femoral nerve block, and then the contents of postoperative serum pain-promoting-related mediators, pain-suppressing-related mediators and pain-related signal molecules were detected.Results: Serum CGRP, PS, Hist, 5-HT, AM and BK contents of experimental group were significantly lower than those of control group, AEA,β-EP, RvE1, LXA4 and LXB4 contents were significantly higher than those of control group, and P2X2, P2X7, P2X3, P2X4, P2Y1, P2Y2, P2Y4, P2Y6, P2Y13, P2Y14, p38MAPK and PI3K contents were significantly lower than those of control group.Conclusions: Continuous femoral nerve block combined with infiltration anesthesia after total knee replacement can increase the generation of pain-suppressing mediators, decrease the generation of pain-promoting mediators and achieve more exact analgesic effect.