Protective effect of dexmedetomidine on neurological function of patients with intravenous inhalational anesthesia and the possible molecular mechanism

摘要

Objective:To study the protective effect of dexmedetomidine on neurological function of patients with intravenous inhalational anesthesia and the possible molecular mechanism. Methods: A total of 88 patients who received surgery under intravenous inhalational anesthesia in our hospital from July 2012 to December 2015 were selected for study, DEX group received dexmedetomidine combined with intravenous inhalational anesthesia, control group received conventional intravenous inhalational anesthesia, and then neurological function indexes as well as the contents of serum invasive cytokines and protective cytokines, the contents of nerve injury-caused highly expressed proteins and the contents of signaling pathway molecules were compared between two groups.Results: D(a-jv)O2 and CERO2 levels as well as serum MBP, NSE and S100β contents of DEX group were significantly lower than those of control group; serum NGF and BDNF contents of DEX group were significantly higher than those of control group, and serum NF-kB, TNF- , IL-1β, IL-6, iNOS, CRMP-2, NKCC1 and AQP4 contents were significantly lower than those of control group.Conclusions:Dexmedetomidine has protective effect on neurological function of patients with intravenous inhalational anesthesia, and its molecular mechanism includes increasing the generation of protective cytokines, inhibiting the generation of invasive cytokines and regulating the activation of neurological function-related signaling pathways.