Objective:To explore the effect of open cholecystectomy (OC) and laparoscopic cholecystectomy (LC) on the body immune function.Methods:A total of 80 patients who were admitted in our hospital from October, 2014 to September, 2015 for cholecystectomy were included in the study and divided into the observation group (LC) and the control group (OC) according to different surgical methods. The patients in the two groups were performed with the operation under general anesthesia and tracheal intubation. The patients in the observation group were performed with LC, while the patients in the control group were performed with OC. The morning fasting venous blood 1 d before operation and 1 d and 7 d after operation was collected. The levels of IgA, IgG, IgM, and peripheral blood CD3+, CD4+, and CD8+ were determined. The ratio of CD4+/CD8+ was calculated.Results: The levels of IgA, IgG, and IgM 1 d after operation in the two groups were significantly reduced when compared with 1 d before operation, the levels 7 d after operation recovered near to those 1 d before operation, but the comparison before and after treatment was not statistically significant. The levels of peripheral blood CD3+, CD4+, and CD4+/CD8+ 1 d after operation were significantly reduced, but CD8+ was significantly elevated. The levels of peripheral blood CD3+, CD4+, and CD4+/CD8+ 7 d after operation were significantly increased, but CD8+ was significantly reduced. The changes of various indicators and the recovering in the observation group were significantly superior to those in the control group.Conclusions:LC has a small effect on the body immune function with a rapid postoperative recovery, showing the advantage of minimal invasiveness with a safety and reliability; therefore, it deserves to be widely recommended in the clinic.
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