Effection of saxagliptin therapy on elderly patients with type 2 diabetes on pancreaticβ-cell function and micro-inflammatory state

摘要

Objective:To explore the effection of saxagliptin therapy on elderly patients with type 2 diabetes on pancreaticβ-cell function and micro-inflammatory state.Methods:A total of 150 cases of elderly patients with type 2 diabetes were randomly divided into A, B, C three groups, and each 50 cases, A group received metformin treatment, B group given saxagliptin treatment, C group given saxagliptin and metformin treatment, observed three groups of patients isletβ cell function index and microinflammation improve situation after three months of treatment. Results: (1) After three months of treatment, FPG, P2hPG, HbA1c levels in three groups were significantly lower than before treatment, The levels of FPG, P2hPG, HbA1c in group C lower than group A and group B after treatment, and group B were lower than that of group A, All the above differences were statistically significant; (2) After three months of treatment, FIns, HOMA-B levels in groups of B and C were higher than before treatment and group A, which were significant differences; (3) After three months of treatment, the serum of CRP, IL-6, LPS levels in the three groups were significantly reduced than before treatment, After treatment, the serum of CRP, IL-6, LPS levels in group C were lower than group A and group B, and group B were lower than that of group A, All the above differences were statistically significant. Conclusion:Saxagliptin treatment of elderly patients with type 2 diabetes to improve the function and micro aspects of isletβ cell inflammation than metformin, combine with metformin the treatment better.