Effect of creatine phosphate sodium combined with spleen amino peptide on hand-foot-mouth disease in children with myocardial damage

摘要

Objective:To explore the clinical effect of creatine phosphate sodium combined with spleen aminopeptide on treatment of hand-foot-mouth disease in children with myocardial damage. Methods:A total of 86 cases with hand-foot-mouth disease combined with cardiac damage in our hospital from January 2012 to July 2014 were randomly divided into the observation group and the control group with 43 cases in each group. Patients in the control group received conventional treatment while observation group patients were treated with creatine phosphate sodium combined with spleen amino peptide treatment. Hs-CRP, myocardial enzymes indexes, serum cytokines, NT-proBNP, PCT, endotoxin, D-lactate and immune related indicators were compared between two groups of children after treatment.Results:In observation group patients' serum IL-4, IL-6 and IL-17 levels were lower than those of of the control group after treatment (P < 0.05) while IFN-γ and IL-10 levels were higher than those of the control group (P < 0.05). In observation group patients' NT-proBNP, PCT, endotoxin and D-lactate levels were lower than those of the control group after treatment (P < 0.05). In observation group patients’ CD3+, CD4+ T lymphocytes, IgA, IgM and IgG levels were higher than those of the control group after treatment while CD8+ T lymphocyte level was lower than that of the control group (P < 0.05).Conclusions:Creatine phosphate sodium combined with spleen amino peptide treatment can effectively protect myocardial and regulate immune as well as optimize systemic inflammatory state.