Value of impulse oscillometry in evaluating the illness in children with asthma and analysis of its correlation with serum indicators

摘要

Objective:To Value of impulse oscillometry in evaluating the illness in children with asthma and its correlation with serum indicators.Methods:Children with asthma attack, children with asthma remission and healthy children were selected for study, impulse oscillometry was conducted to obtain related parameters, and serum and peripheral blood were collected to detect related indicators.Results:Zrs, R5, R20, R5-R20, absolute value of X5 and Fres of asthma attack group and asthma remission group were higher than those of control group, eosinophil, YKL-40, Hes-1, Cyr61, Eotaxin, IgE, IgG4, LT-B4, LT-C4, LT-D4 and Cys-LT contents in peripheral blood were higher than those of control group, positive proportion of Th2, Th17, cTfh and Th19 in peripheral blood were higher than those of control group, and positive proportion of Th1 and Treg in peripheral blood were lower than those of control group; the changes of above indicators of asthma attack group were more significant than those of asthma remission group; Zrs, R5, R20, R5-R20, absolute value of X5 and Fres were positively correlated with eosinophil, YKL-40, Hes-1, Cyr61, Eotaxin, IgE, IgG4, LT-B4, LT-C4, LT-D4 and Cys-LT contents in peripheral blood as well as positive proportion of Th2, Th17, cTfh and Th19 in peripheral blood, and negatively correlated with positive proportion of Th1 and Treg in peripheral blood.Conclusion:Impulse oscillometry detection can provide evidence for diagnosis of bronchial asthma and judgment of its illness, and IOS-related parameters can judge the abnormal degree of inflammatory response and immune response.