Effect of Qingqi Huatan decoction on serum indicators and induced sputum indicators in children with cough variant asthma

摘要

Objective:To analyze the effect of Qingqi Huatan decoction on serum indicators and induced sputum indicators in children with cough variant asthma.Methods:A total of 118 cases of children with cough variant asthma were included for study, and all were treated in our hospital from August 2012 to December 2014. According to random principle, included children were divided into observation group (n=59) and control group (n=59). Control group received conventional treatment, observation group received conventional treatment combined with Qingqi Huatan decoction treatment, and then serum, induced sputum and airway anatomy indicators were compared between two groups.Results:ECP, SP, NGF, IL-5 and IL-13 levels in induced sputum of observation group after treatment were lower than those of control group, and TLR2 level was higher than that of control group; serum MIP-1α, Eotaxin, SAA, SIgE and TIgE values of observation group after treatment were lower than those of control group; serum leukotriene B4, leukotriene C4 and leukotriene D4 levels of observation group after treatment were lower than those of control group; AI, AO, T, WA and WA% values of observation group after treatment were lower than those of control group.Conclusion:Qingqi Huatan decoction for children with cough variant asthma can effectively reduce systemic inflammatory response and allergy-related factor generation and reverse airway remodeling process, and it has active clinical significance.