Study of recurrence and serum indicator change after levetiracetam treatment of children febrile convulsion

摘要

Objective:To analyze the recurrence and serum indicator change after levetiracetam treatment of children febrile convulsion.Methods:A total of 92 cases of children with febrile convulsion who received treatment in our hospital from March 2012 to December 2014 were selected as research subjects and randomly divided into observation group and control group according to different treatment methods, each group with 46 cases. Control group received conventional therapy, observation group received levetiracetam combined with conventional therapy, and then differences in recurrence of febrile convulsion, cranial nerve-related factors, contents of trace elements and iron as well as humoral and cellular immune function of two groups were compared.Results:Average number of fever, frequency of recurrence of convulsion and the proportion of developing to epilepsy of observation group after treatment were less than those of control group, and the time from the end of treatment to the first convulsive seizure was longer than that of control group; serum NSE, S-100β and BDNF levels of observation group after treatment were lower than those of control group; serum Ca2+, P, SI and SF levels of observation group after treatment were higher than those of control group, and ALP level was lower than that of control group; serum IgA, IgM, IgG and CD8+ levels of observation group after treatment were lower than those of control group, and levels of CD4+ and CD4+/ CD8+ were higher than those of control group.Conclusion:Levetiracetam therapy for children with febrile convulsion reduces convulsive seizure and meantime can optimize children’s microenvironment and enhance immune function.