Clinical assessment of low dose of dopamine combined with dobutamine and conventional treatment on children with severe pneumonia

摘要

Objective:To analyze the clinical effect of low dose of dopamine combined with dobutamine combined with conventional treatment of severe pneumonia in children.Methods:A total of 218 cases of children with severe pneumonia treated in our hospital from August 2011 to May 2014 were enrolled for study and divide into observation group and control group according to different treatment methods. Control group received conventional treatment, observation group received low dose of dopamine combined with dobutamine combined with conventional treatment, and then differences in symptomatic relief time, blood gas indexes, inflammatory factor levels and pulmonary surfactant protein levels between two groups were compared. Results:Time that temperature subsided, time that difficulty in breathing was relieved, time that heart rate returned to normal and time that pulmonary rale disappeared of observation group after treatment were all shorter than those of control group; 3 d and 7 d after treatment, PaO2 and HCO3 levels in arterial blood of observation group were higher than those of control group, and PaCO2 level was lower than that of control group; serum IL-1β, IL-6, TNF-α, sICAM-1 and CRP levels of observation group 7 d after treatment were lower than those of control group at the same period, and IL-10 level was higher than that of control group; 7 d, 10 d and 14 d after treatment, serum SP-A, SP-B, SP-C and SP-D levels of observation group were significantly lower than those of control group.Conclusion:Adding low dose of dopamine and dobutamine to treatment of children with severe pneumonia can promote the improvement of clinical symptoms, reduce systemic inflammation, optimize pulmonary ventilation and aeration function while reduce lung parenchyma damage, and it has active clinical significance.