Objective:To explore the clinical value of serum β-HCG, P, CA125, and color Doppler ultrasound in the early diagnosis of ectopic pregnancy (EP). Methods:A total of 50 patients with EP who were admitted in our hospital from September, 2014 to September, 2015 were included in the study and served as the observation group, while 50 normal pregnant women were served as the control group. A volume of 5 mL of fasting elbow venous blood the day on admission in the two groups was extracted, and then was centrifuged for serum. The chemiluminescence immunoassay was used to detect the levels of serum β-HCG, P, and CA125. After 48h,β-HCG level was detected again. The vaginal color Doppler diasonograph was used to detect the changes of RI and PSV. The blood supply of LH was observed. Results:The levels of serumβ-HCG, P, and CA125 in the observation group were significantly lower than those in the control group (P<0.05). When β-HCG<2 000 IU/L, after 48 h, β-HCG level was doubled in 3 cases (6.0%) in the observation group, while in 49 cases (98.0%) in the control group, and the differences between the two groups were not statistically significant (P<0.05). RI in the observation group was significantly higher than that in the control group, while PSV was significantly lower than that in the control group (P<0.05). Blood supply in the observation group was in a half ring shape, accounting for 58.0%;in the control group was in a ring shape, accounting for 70.0%, and the difference was statistically significant (P<0.05). Conclusions:Determination of the levels of serumβ-HCG, P, and CA125 in the pregnant women, in combined with the vaginal color Doppler ultrasound detection of RI and PSV, can contribute to distinguish the normal intrauterine pregnancy with EP and prevent the misdiagnosis, which can provide an accurate reference value for the early diagnosis and timely treatment of EP, and can be used as an ideal method for the diagnosis of EP.
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