Objective:To discuss the time course changes of NADPH-d positive neuron counts in the cortex of mice after acute heat stress. Methods:Model of mice after acute heat stress were duplicated. Shuttle box test was used to observe the learning and memory function of mice at 6 h, 12 h, 24 h respectively after heat stress. NADPH-d histochemical staining test was used to observe the time course changes of NADPH-d positive neuron counts in the cortex of mice at 6 h, 12 h, 24 h respectively after heat stress. Results:(1) Shuttle box test indicated that:Compared with control group, mistakes (M) in HS (heat stress) group was significantly increased while escape latency (EL) was significantly shortened at 6 h, 12 h respectively. (2) NADPH-d histochemical staining test indicated that:Compared with control group, NADPH-d positive neuron counts in HS group were significantly increased at 6 h, and difference had statistical significance. NADPH-d positive neuron counts in HS group were significantly decreased at 12 h. Conclusion:Acute heat stress could result in obvious damages on learning and memory function of mice, which was possibly related with the increased NADPH-d positive neuron expression.
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