Vitamin C combined with atorvastatin calcium state of micro oxidative stress and inflammation in patients with hemodialysis

摘要

Objective:To discuss Vitamin C combined with statins atorvastatin calcium affect oxidative stress in hemodialysis patients with micro-inflammatory state.Methods:92 hemodialysis patients admitted to hospital were randomly divided into atorvastatin calcium group (A) and vitamin C combined with atorvastatin calcium group (group B), select the same period and 30 healthy volunteers as group C, compare three groups before and after treatment with the micro-inflammatory state of oxidative stress indexes, including malondialdehyde (MDA), superoxide dismutase (SOD), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α) levels in the case.Results:Group A Group B and MDA levels before treatment were significantly higher than group C, after treatment indicators were significantly lower than before treatment, and group B index level change is more significant, the difference was statistically significant (P<0.05); two SOD levels before treatment were significantly higher than group C, the target level after treatment was significantly lower than before treatment, and the B group index change is more obvious, the difference was statistically significant (P<0.05);A group and group B before treatment were significantly higher than the index of water group C, were significantly decreased after treatment than before treatment groups level, and group B decreased more significantly, the difference was statistically significant (P<0.05).Conclusions:Vitamin C combined with atorvastatin calcium can improve hemodialysis patients oxidative stress and micro-inflammatory state, fewer adverse reactions, is worthy of clinical application.