Objective:To discuss the effect of salvianolate injection on related indexes of patients with cerebral infarction.Methods:84 cases of patients with cerebral infarction from October 2013 to October 2014 were selected and all patients suffered from thrombosis cerebral infarction. All patients were divided into control group and study group according to digital table method (n=42). Patients in control group were given individualized treatment, like nutrition, encephaledema elimination, thrombolytic treatment, according to their staging and individual actual situations. On the basis of control group, patients in study group were given salvianolate injection treatment. Endothelin-1 (ET-1), thrombomodulin (TM), blood platelet count, TXB2, 6-ketone-PGF1α, antithrombin-Ⅲ (AT-Ⅲ), protein C, protein S, coagulation time, APTT , fibrinolysis activity: plasminogen activity loss: t-PA and PAI, plasma viscosity (ηb) in both groups before and after treatment were compared.Results:2 weeks after treatment, ET-1, TM, blood platelet count, TXB2, PAI-1,ηb, whole blood viscosity in both groups were decreased, and compared with before treatment, difference had statistical significance (P<0.05); while 6-ketone-PGF1α, coagulation time, APTT, antithrombin-Ⅲ, protein C, protein S, plasma t-PA in both groups were increased, and compared with before treatment, difference had statistical significance (P<0.05). After treatment, ET-1, TM, TXB2,ηb in study group were obviously lower than that in control group, and comparison between groups had statistical significance (P<0.05), 6-ketone-PGF1α, antithrombin-Ⅲ, protein C, t-PA in study group were obviously higher than that in control group, and comparison between groups had statistical significance (P<0.05). Conclusions:Salvianolate injection adjuvant therapy in patients with thrombosis cerebral infarction could improve the related indexes of thrombus and had positive significance to the follow-up recovery of patients.
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