The study of clinical value of repetitive transcranial magnetic stimulation combined with dutoxetine for patients with generalized anxiety disorder

摘要

Objective:To analyze the clinical value of repetitive transcranial magnetic stimulation (RTMS) combined with dutoxetine for patients with generalized anxiety disorder (GAD).Methods:A total of 180 cases of patients with GAD were randomly divided into two groups (the control group and the observation group) with 90 cases each group. Patients in control group were treated with dutoxetine, while those in observation group were treated by dutoxetine combined with RTMS. The Hamilton anxiety scale and the clinical global impression scale were used to evaluate the efficacy of both groups before and after treatment, then the characteristics of mismatch negativity and P300 were detected by using brain evoked potential, and meanwhile, plasma cortisol, brain derived neurotrophic factor and homocysteine levels were detected and compared too.Results:Analysis of variance of repeated measure data showed that the main effect of time, main effect between groups and interaction effect of Hamilton anxiety scale and the clinical global impression scale scores, MMN incubation period, MMN amplitude, target N2 incubation period, target P3 incubation period, P2 non-target amplitude, levels of plasma cortisol, brain derived neurotrophic factor and homocysteine of both groups were statistically significant (P < 0.05).Conclusions:The treatment of RTMS combined with dutoxetine for patients with GAD has a faster and better curative effect, which is worthy of clinical promotion.