Correlation between serumβ2 microglobulin and early kidney injury post neonatal asphyxia

摘要

Objective:To investigate serumβ2 microglobulin and neonatal asphyxia early renal damage correlation.Methods:A total of 84 suffocation full-term newborns in our hospital from 2012 March to 2014 November. According to the Apgar standards, divided into severe asphyxia group (n=36) and mild asphyxia group (n=48), and selected 40 cases of full-term newborn, observed blood and urinaryβ2-MG, albumin (Alb) blood urea nitrogen (BUN), creatinine (Cr) level.Results:severe asphyxia groupβ2-MG (6.02±0.96) mg/L was the highest, followed by mild asphyxia group, lowest in the control group; severe asphyxia group Alb, BUN and Cr were (22.15±6.17) mg/L, (10.01±1.84) mmol/L and (120.16±28.13)μmol/L, significantly higher than the mild asphyxia group and the control group; Mild asphyxia group and the control group Alb, BUN and Cr were not statistically significant; three groups birth 48 h,β2-MG, Alb, serum BUN and Cr showed significant differences, in which the severe asphyxia groupβ2-MG, Alb, BUN and Cr were the highest, and lowest in the control group; Severe asphyxia group was the highestβ2-MG, (7.12±1.32) mg/L; serumβ2-MG were positively associated with urineβ2-MG.Conclusion: Serumβ2-2 microglobulin in judging neonatal asphyxia early renal damage is more sensitive, and has clinical practical value.