Expression and significance of NF-κB, TGF-β1 and other biochemical indicators in patients with polycystic ovary syndrome

摘要

Objective: To explore the expression and significance of serum NF-κB, TGF-β1, VEGF, sFlt-1, leptin, adiponectin, LH, FSH and PRL in patients with polycystic ovary syndrome by comparing serum levels of the various biochemical indicators among the cases. Methods:A total of 30 patients with polycystic ovary syndrome in our hospital from May 2016 to June 2017 were selected as the observation group. At the same time, 30 patients who were treated for other causes of infertility or tubal ovarian cysts were selected as control group. ELISA method was used to detect the serum levels of NF-κB, TGF-β1, VEGF, sFlt-1. Radioimmunoassay was used to detect the serum levels of leptin and adiponectin. Chemiluminescence immunoassay was used to detect the serum levels of LH, FSH and PRL. Results: The serum NF-κB, TGF-β1, VEGF, leptin, LH levels of observation group were significantly higher than control group. The serum sFlt-1, adiponectin, FSH and PRL levels of observation group were significantly lower than control group. The differences were statistically significant. Conclusion: NF-κB, TGF-β1, VEGF, sFlt-1, leptin, adiponectin, LH, FSH and PRL may play a role in pathogenesis of PCOS.