Effects of standardized three-stage rehabilitation combined with edaravone therapy on the neurotrophic state and oxidative stress injury in patients with cerebral infarction

摘要

Objective: To investigate the effects of standardized three-stage rehabilitation combined with edaravone therapy on the neurotrophic state and oxidative stress injury in patients with cerebral infarction. Methods: A total of 90 patients with acute cerebral infarction who were treated in the hospital between May 2015 and April 2017 were divided into control group (n=45) and observation group (n=45) by random number table. Control group received edaravone therapy, and observation group received standardized three-stage rehabilitation combined with edaravone therapy. The differences in neurotrophic state and oxidative stress injury were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of neurotrophic indexes and oxidative stress indexes between the two groups before treatment. After treatment, serum neurotrophic indexes BDNF and NGF levels of observation group were higher than those of control group;serum oxidation indexes AOPPs, LHP and MDA levels were lower than those of control group whereas SOD, CAT and T-AOC levels were higher than those of control group. Conclusion:Standardized three-stage rehabilitation combined with edaravone therapy can effectively optimize the neurotrophic state and inhibit the oxidative stress in patients with cerebral infarction.