Effect of Xingnaojing Injection on inflammatory cytokines and blood coagulation function in patients with acute cerebral hemorrhage

摘要

Objective: To investigate the effect of Xingnaojing Injection on inflammatory cytokines and blood coagulation function in patients with acute cerebral hemorrhage. Method: A total of 80 patients with acute cerebral hemorrhage admitted to our hospital from October 2015 to May 2017 were randomly divided into the observation group and the control group, each group with 40 cases. Two groups both received conventional treatment; the observation group was given Xingnaojing injection additionally. The two groups were treated for two weeks. Changes of serum inflammatory factors TNF-α, hs-CRP, IL-10 and blood coagulation indexes of activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fib), thrombin time (TT) and D-dimer (DD) of two groups were compared. Results: Before treatment, the differences of inflammatory factors TNF-α, hs-CRP, IL-10 and coagulation function indexes APTT, PT, Fib, TT and DD of the two groups were not statistically significant. After treatment, the levels of TNF-α, hs-CRP of the two groups were significantly decreased, and the IL-10 level of the two groups were significantly increased; the levels of TNF-α, hs-CRP in observation group were significantly lower than the control group, and the IL-10 level in observation group were significantly higher than the control group. After treatment, the levels of APTT, Fib and DD in the control group were significantly increased; the levels of PT and DD in the observation group were significantly decreased and the Fib level was significantly increased. After treatment, the levels of APTT, PT and DD in the observation group were significantly lower than those in the control group, and Fib level was significantly higher than that in the control group, these differences were statistically significant. There was no significant difference of TT levels between the two groups before and after the treatment. Conclusion: Xingnaojing injection treatment of acute cerebral hemorrhage can significantly reduce the level of serum inflammatory factors and promote the restoration of coagulation function. It is worth promoting.