Effect of ropivacaine fascia iliaca compartment block combined with dezocine multimodal analgesia on the pain and stress response after hip replacement

摘要

Objective: To study the effect of ropivacaine fascia iliaca compartment block combined with dezocine multimodal analgesia on the pain and stress response after hip replacement. Methods: A total of 74 cases of elderly patients who received hip replacement in Mianyang Central Hospital between December 2015 and June 2017 were selected and randomly divided into multimodal analgesia group (MMA group), and patient-controlled intravenous analgesia group (PCIA group), MMA received ropivacaine fascia iliaca compartment block, dezocine preemptive analgesia combined with patient-controlled intravenous analgesia, and PCAI group received patient-controlled intravenous analgesia. The levels of pain-related molecules and stress-related hormones in serum as well as the levels of stress-related immune molecules in peripheral blood were detected immediately after surgery and 12 h after surgery. Results: 12 h after surgery, serum SP, PGE2, TNF-α, IL-1β, IL-10, FC, NE, E and GH levels and peripheral blood Foxp3+ cell fluorescence intensity of both groups of patients were significantly higher than those immediately after surgery, peripheral blood CD3+, CD4+, CD8+ cell fluorescence intensity were significantly lower than those immediately after surgery, serum SP, PGE2, TNF-α, IL-1β, IL-10, FC, NE, E and GH levels and peripheral blood Foxp3+ cell fluorescence intensity of MMA group 12 h after surgery were significantly lower than those of PCIA group, and peripheral blood CD3+, CD4+, CD8+ cell fluorescence intensity were significantly higher than those of PCIA group. Conclusion: Ropivacaine fascia iliaca compartment block combined with dezocine multimodal analgesia can reduce the pain and stress response after hip replacement.