Study on the relationship between serum inflammatory factors and systemic target organ damage in severe acute pancreatitis patients

摘要

Objective: To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis. Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined. Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group; serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels. Conclusion: Abnormal release of inflammatory factors in serum of SAP patients can cause liver function, renal function and intestinal mucosal barrier function injury.