Changes of CT dynamic contrast-enhanced scan parameters in patients with lung cancer before and after radiofrequency ablation

摘要

Objective:To study the changes of CT dynamic contrast-enhanced scan parameters in patients with lung cancer before and after radiofrequency ablation (RFA) and their correlation with serum tumor markers.Methods:A total of 60 patients who were diagnosed with lung adenocarcinoma in the Second Hospital of Yulin City between May 2015 and January 2017 were selected and randomly divided into the RFA group and control group who received RFA combined with GP chemotherapy and GP chemotherapy alone respectively. Before and after treatment, CT dynamic contrast-enhanced scan was performed to calculate blood perfusion parameters, and serum was collected to determine the contents of cancer cell proliferation activity molecules, angiogenesis molecules and cell invasion molecules.Results: After treatment, BF, BV, MTT and PS levels as well as serum CYFRA21-1, SCC-Ag, TK-1, HE-4, TPS, HDGF, VEGF, PCDGF, bFGF, NGAL, MMP7, MMP9 and OPN contents of both groups of patients were significantly lower than those before treatment, and BF, BV, MTT and PS levels as well as serum CYFRA21-1, SCC-Ag, TK-1, HE-4, TPS, HDGF, VEGF, PCDGF, bFGF, NGAL, MMP7, MMP9 and OPN contents of RFA group after treatment were significantly lower than those of control group.Conclusions:The changes of CT dynamic contrast-enhanced scan parameters in patients with lung cancer before and after radiofrequency ablation suggest that the blood perfusion significantly reduces and is closely related to cancer cell proliferation and invasion as well as angiogenesis.