Curative effect of singulair combined with methylprednisolone in treatment of mycoplasma pneumonia and the effect on inflammatory response and peripheral blood lymphocyte subset content

摘要

Objective:To study the effect of Singulair combined with methylprednisolone treatment on inflammatory response and peripheral blood lymphocyte subset content in children with mycoplasma pneumonia.Methods:74 children with severe mycoplasma pneumonia who were treated in Huai'an Second People's Hospital between June 2014 and October 2016 were selected as the research subjects and randomly divided into two groups, the intervention group received routine treatment combined with Singulair and methylprednisolone, and control group received routine treatment. Before and after treatment, serum was collected to detect the contents of inflammatory cytokines and corresponding cytokines of T lymphocyte subsets, and peripheral blood was collected to determine the contents of T cell subsets.Results:3 d and 7 d after treatment, serum MCP-1, PCT, ICAM-1, CXCL8, CRP, IFN-γ and IL-17 contents as well as peripheral blood Th1 and Th17 contents of both groups were significantly lower than those before treatment while serum IL-4 and TGF-β contents as well as peripheral blood Treg and Th2 contents were significantly higher than those before treatment, and serum MCP-1, PCT, ICAM-1, CXCL8, CRP, IFN-γ and IL-17 contents as well as peripheral blood Th1 and Th17 contents of intervention group were significantly lower than those of control group while serum IL-4 and TGF-β contents as well as peripheral blood Treg and Th2 contents were significantly higher than those of control group.Conclusion: Singulair combined with methylprednisolone treatment of mycoplasma pneumonia can inhibit the inflammatory response and regulate the balance of Th1/Th2 and Th17/Treg cells.