Tei index in preeclampsia pregnant women and its correlation with the degree of endothelial injury and hypertension

摘要

Objective:To study the Tei index in preeclampsia pregnant women and its correlation with the degree of endothelial injury and hypertension.Methods: A total of 98 preeclampsia pregnant women who were treated in our hospital between May 2014 and July 2016 were divided into mild preeclampsia group (n=62) and severe preeclampsia group (n=36), and 50 normal pregnant women who received antenatal care in our hospital during the same period were selected as normal control group. Ultrasound Tei index as well as the levels of serum endothelial injury indexes and hypertension-related indexes were compared among three groups of pregnant women, and the correlation of Tei index with endothelial injury and hypertension level in preeclampsia pregnant women was further evacuated.Results: Tei index levels in mild preeclampsia group and severe preeclampsia group were higher than that in normal control group, and the Tei index level in severe preeclampsia group was higher than that in mild preeclampsia group. Serum VEGF contents in mild preeclampsia group and severe preeclampsia group were lower than that in the normal control group while sFlt-1, MMP-1 and PAR-1 contents were higher than those in normal control group, 24 h SBP, 24 h DBP, dSBP, dDBP, nSBP and nDBP levels were higher than those in normal control group, and the changes in above indexes in severe preeclampsia group were higher than those in mild preeclampsia group. The Pearson test showed that the Tei index level in preeclampsia pregnant women was directly correlated with endothelial injury and hypertension level.Conclusion: Tei index increases in preeclampsia pregnant women, and its level is directly correlated with endothelial injury and hypertension level.