Serum vitamin and microelement nutrition of children with pneumonia and their relationship with the inflammatory state and immune response

摘要

Objective:To analyze the serum vitamin and microelement nutrition of children with pneumonia and explore their relationship with the inflammatory state and immune response. Methods:A total of 78 children with pneumonia who were treated between May 2014 and May 2016 were collected as the observation group, and 50 health children who received vaccination in our hospital during the same period were collected as the normal control group. High performance liquid chromatography was used to determine serum vitamin A (VitA) content, atomic absorption spectrometry was used to determine serum Fe content, and the median VitA and Fe contents were used to further divide the observation group into high VitA group and low VitA group as well as high Fe group and low Fe group, 39 cases in each group. The inflammatory and immune response state in pneumonia children with different VitA and Fe contents were determined.Results:Serum VitA and Fe contents of observation group were lower than those of normal control group; serum inflammatory cytokines IL-6, PCT, sTREM-1 and CRP contents as well as humoral immunity indexes IgG, IgA and IgM contents of low VitA group and high VitA group were higher than those of normal control group, and as serum VitA content reduced, the inflammatory and immune response were enhanced; serum inflammatory cytokines IL-6, PCT, sTREM-1 and CRP contents as well as humoral immunity indexes IgG, IgA and IgM contents of low Fe group and high Fe group were higher than those of normal control group, and as serum Fe content reduced, the inflammatory and immune response were enhanced.Conclusion: Serum VitA and Fe contents were low in children with pneumonia, and their contents are negatively correlated with the inflammatory state and humoral immune response degree.