Influence of Pimecrilimus Cream therapy on serum inflammatory factors and immune function levels of patients with eczematous dermatitis

摘要

Objective:To investigate influence of Pimecrilimus Cream therapy on serum inflammatory factors and immune function of patients with eczematous dermatitis.Methods: A total of 112 cases of patients with eczematous dermatitis treated in our hospital from Mar 2015 to May 2016 were selected and randomly divided into the control group and observation group, 56 cases each. For control group, Hydrocortisone butyrate onitment therapy was utilized. For observation group, 1% Pimecrilimus cream was used for treatment. Variations of interferon inflammation factors-γ (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10) levels and immune function (T lymphocyte subsets CD3+, CD4+, CD8+) relevant indexes in two groups of patients before and one month after treatment were observed and compared.Results:Comparison of inflammatory factor levels: IFN-γ, IL-4 and IL-10 levels in two groups of patients after treatment were decreased with different extent comparing with the same group before treatment, differences were significant. IFN-γ, IL-4 and IL-10 levels in observation group (31.27±6.45, 30.54±5.64, 38.66±4.73) ng/L were lower than levels in control group after treatment (37.49±5.69, 36.44±5.51, 55.31±4.62) ng/L, differences were significant;Comparison of immune function levels: CD3+ and CD4+ levels in two groups of patients after treatment were significantly increased comparing with the same group before treatment, CD3+, CD4+ levels in observation group after treatment (65.53±3.31, 34.55±2.27)% were higher than levels in control group after treatment (60.38±3.16, 32.65±2.16)%, differences were significant; Levels of CD8+ concentration in two groups of patients after treatment were significantly decreased comparing with the same group before treatment. CD8+ levels in observation group after treatment (24.17±2.05)% were lower than control group after treatment (27.63±2.46)%, differences were significant.Conclusion:1% Pimecrilimus cream treatment could effectively improve serum inflammatory factor levels and immune function of patients with eczematous dermatitis, which deserved clinical expansion.