Effect of edaravone in combined with rTMS on the free radicals and neurological function in patients with cerebral infarction

摘要

Objective:To explore the effect of edaravone in combined with repetitive transcranial magnetic stimulation (rTMS) on the free radicals and neurological function in patients with cerebral infarction.Methods: A total of 90 patients with acute cerebral infarction (ACI) who were admitted in our hospital from September, 2015 to March, 2016 were included in the study and randomized into the observation group and the control group. The patients in the control group were given blood pressure reduction, intracranial pressure reduction, blood lipid regulation, anti-platelet aggregation, symptomatic and supportive treatments, edaravone (30 mg) + normal saline (100 mL), ivdrip, 2 times/d, continuously for 14 d. On this basis, the patients in the observation group were given additional rTMS. 7 d-treatment was regarded as one course, and the patients were treated for 4 courses. The morning fasting venous blood before treatment, 7 d and 14 d after treatment in the two groups was collected to detect NO, NOS, SOD, MDA, S-100β, and NSE. NIHSS before treatment, 7 d, 14 d, and 28 d after treatment was evaluated.Results:NO, NOS, and MDA levels after treatment in the observation group were significantly lower than those in the control group, while SOD level was significantly higher than that in the control group. S-100β and NSE levels after treatment in the observation group were significantly lower than those in the control group. NIHSS score after treatment in the observation group was significantly lower than that in the control group.Conclusions:Edaravone in combined with rTMS in the treatment of ACI can significantly eliminate the free radicals, effectively improve the neurological function, and enhance the long-term efficacy.