The correlation of PCT, SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis

摘要

Objective:To study the correlation of PCT, SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis.Methods: A total of 35 neonates diagnosed with sepsis in our hospital between March 2014 and March 2016 were selected as the sepsis group of the study, 60 healthy neonates born in our hospital during the same period were selected as the control group, peripheral blood samples were collected to determine the levels of PCT, SAA, CD64 as well as inflammatory factors, myocardial injury marker molecules and liver injury marker molecules.Results:PCT, SAA, CD64, sTREM-1, TNF-α, IL-6, IL-8, cTnI, cTnT, H-FABP, CK-MB, AST, ALT, GGT, TBIL and DBIL levels in peripheral blood of sepsis group were significantly higher than those of control group; PCT, SAA and CD64 levels in peripheral blood were positively correlated with sTREM-1, TNF-α, IL-6, IL-8, cTnI, cTnT, H-FABP, CK-MB, AST, ALT, GGT, TBIL and DBIL levels. Conclusion: PCT, SAA and CD64 levels in peripheral blood of neonatal sepsis significantly increase and are associated with the degree of inflammation, myocardial injury and liver injury.