Objective:To study the correlation of serum Exosome and Dickkopf-1 content with pathological process and gene expression in patients with gastric cancer.Methods:A total of 480 patients diagnosed with gastric cancer in our hospital between May 2015 and July 2016 were selected as the gastric cancer group and 220 healthy volunteers receiving physical examination during the same period were selected as control group. Serum was collected to detect Exosome and Dickkopf-1 content, and gastric cancer tissue and para-carcinoma tissue were collected to detect the expression of pro-proliferation and pro-invasion molecules as well as tumor suppressor genes.Results:Serum Exosome and Dickkopf-1 content of gastric cancer group were significantly higher than those of control group and the deeper the infiltration and the worse the differentiation, the higher the serum Exosome and Dickkopf-1 content, and serum Exosome and Dickkopf-1 content in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis; UHRF1, SIRT1 and LOXL2 expression in gastric cancer tissue were significantly higher than those in para-carcinoma tissue and positively correlated with serum Exosome and Dickkopf-1 content while RASAL2, ING5, Period1 and Period2 expression were significantly lower than those in para-carcinoma tissue and negatively correlated with serum Exosome and Dickkopf-1 content. Conclusion:The elevated serum Exosome and Dickkopf-1 in patients with gastric cancer are closely related to the high expression of pro-proliferation and pro-invasion molecules as well as the low expression of proto-oncogene.
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