Effect of Bijia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis

摘要

Objective: To detect the effect of BiJia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis. Methods: A total of 94 patients with chronic hepatitis B combined with cirrhosis admitted in the hospital from January 2017 to December 2017 were selected as the subjects, and they were randomly divided into 47 cases in the observation group and 47 cases in the control group. The control group was given Adefovir Dipivoxil Tablets, and the observation group was treated with Bijia Jian pills on the basis of control group. The changes of liver function, inflammatory factors and liver fibrosis indexes were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in AST, ALT, TBIL and ALB between the two groups. After treatment, the AST, ALT and TBIL of the two groups were all decreased, and the AST, ALT and TBIL in the observation group were lower than those of the control group; the ALB of the two groups increased, and the ALB of the observation group was higher than that of the control group. Before treatment, there was no significant difference in TNF-α, IL-1 βand IL-10 between the two groups. After treatment, the TNF-α and IL-1β of the two groups were decreased, and the TNF-α and IL-1β in the observation group were lower than those of the control group; the IL-10 of the two groups increased, and the IL-10 in the observation group was higher than that in the control group. Before treatment, there was no significant difference in HA, LN, IV-C and PCIII between the two groups. After treatment, the HA, LN, IV-C and PCIII of the two groups were all decreased, and the HA, LN, IV-C and PCIII of the observation group were lower than those of the control group. Conclusion Bijia Jian pills can effectively improve the inflammatory factors and liver fibrosis in patients with chronic hepatitis B complicated with cirrhosis.