Correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions

摘要

Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between January 2017 and January 2018 were divided into TI-RADS grade 4 group (n=54) and TI-RADS grade 5 group (n=56) according to TI-RADS grading. 50 patients who underwent surgery and were diagnosed with thyroid adenoma in this hospital during the same period were chosen as benign thyroid group. The differences in the expression of oncogenes and invasion molecules in lesion tissues were compared among the three groups. Results: Proto-oncogenes c-myc, c-erbB-2, RET and TRK mRNA expression in lesions of TI-RADS grade 4 group and TI-RADS grade 5 group were higher than those of benign thyroid group whereas tumor suppressor genes DPC4, p53, PTEN and HBB mRNA expression were lower than those of benign thyroid group; invasion molecules BCORL1, BRD4, STAT3, CD151, SATB1 and CXCR4 mRNA expression were higher than those of benign thyroid group whereas ST7L mRNA expression were lower than that of thyroid benign group. With the increase of TI-RADS grading, the changes in the expression of oncogenes and invasion molecules were aggravated. Conclusion: The changes in oncogene and invasion molecule expression were aggravated with the increase of TI-RADS grading of thyroid cancer, and the specific TI-RADS grading was positively correlated with tumor malignancy.