Effects of ulinastatin + danshen + somatostatin on inflammation and oxidative stress in patients with severe pancreatitis

摘要

Objective: To explore the effects of ulinastatin + danshen + somatostatin on inflammation and oxidative stress in patients with severe pancreatitis. Methods: A total of 72 patients with severe acute pancreatitis who were treated in this hospital between September 2014 and December 2016 were divided into control group (n=36) and study group (n=36) by random number table method, control group received conventional treatment combined with danshen + somatostatin therapy, and study group received conventional treatment combined with ulinastatin + danshen+ somatostatin therapy. The differences in the levels of systemic inflammation and oxidative stress indexes were compared between the two groups before and after treatment. Results:Immediately after admission, the differences in the serum levels of inflammatory mediators and oxidative stress indexes were not statistically significant between the two groups. After 10 d of treatment, inflammatory mediators IL-1β, IL-6, sICAM-1 and PCT levels in the serum samples of study group were lower than those of control group; oxidation indexes MDA, LHP and AOPPs levels in serum samples of study group were lower than those of control group whereas anti-oxidation indexes SOD, GSH-Px and CAT levels were higher than those of control group. Conclusion: Ulinastatin + danshen + somatostatin therapy can effectively inhibit the inflammation and oxidative stress in patients with severe pancreatitis.