Correlation of LRIG1 and Gadd45g expression in pituitary tumor with the autophagy, apoptosis and invasion of tumor cells

摘要

Objective: To study the correlation of leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) and growth arrest and dna damage 45g (Gadd45g) expression in pituitary tumor with the autophagy, apoptosis and invasion of tumor cells. Methods: Patients with pituitary tumor who underwent surgical resection in our hospital between June 2014 and December 2017 were selected, and the invasive pituitary tumor tissues and noninvasive pituitary tumor tissues were collected; patients who underwent surgery for craniocerebral trauma in our hospital during the same period were selected as the control group, and normal brain tissues were collected; the mRNA expression levels of LRIG1, Gadd45g as well as autophagy, apoptosis and invasion genes in tissue samples were measured. Results: LRIG1, Gadd45g, Beclin1, LC3-II, Bax, NKG2D and E-cadherin mRNA expression in invasive pituitary tumor and noninvasive pituitary tumor tissues were significantly lower than those in normal brain tissues whereas PTTG1, c-Myc, Gal-3, Bcl-2, EphA2, HSP27, MMP14 and VEGF mRNA expression were significantly higher than those in normal brain tissues, and LRIG1, Gadd45g, Beclin1, LC3-II, Bax, NKG2D and E-cadherin mRNA expression in invasive pituitary tumor tissues were significantly lower than those in noninvasive pituitary tumor tissues whereas PTTG1, c-Myc, Gal-3, Bcl-2, EphA2, HSP27, MMP14 and VEGF mRNA expression were significantly higher than those in noninvasive pituitary tumor tissues; LRIG1 and Gadd45g mRNA expression were positively correlated with Beclin1, LC3-II, Bax, NKG2D and E-cadherin mRNA expression, and negatively correlated with PTTG1, c-Myc, Gal-3, Bcl-2, EphA2, HSP27, MMP14 and VEGF mRNA expression. Conclusion: The low expression of LRIG1 and Gadd45g in pituitary tumor can inhibit the autophagy and apoptosis of tumor cells and promote the invasion of tumor cells.