Objective:To study the correlation of miR-106b in nasopharyngeal carcinoma with cell cycle progression and cell invasion.Methods: Patients who were diagnosed with nasopharyngeal carcinoma by pathological biopsy in Shenmu Hospital between March 2013 and February 2018 were included in the study, and the nasopharyngeal carcinoma tissue and tissue adjacent to nasopharyngeal carcinoma obtained from biopsy were collected, miRNA was extracted to determine miR-106b expression, and RNA was extracted to determine the mRNA expression of cell cycle-related genes and cell invasion-related genes.Results: miR-106b expression as well as FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression in nasopharyngeal carcinoma tissues were higher than those in adjacent tissues, CYB5R2, p16, IRF5 and E-cadherin mRNA expression were significantly lower than those in adjacent tissues whereas; CYB5R2, p16, IRF5 and E-cadherin mRNA expression in nasopharyngeal carcinoma tissues with high miR-106b expression were lower than those in nasopharyngeal carcinoma tissues with low miR-106b expression whereas FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression were higher than those in nasopharyngeal carcinoma tissues with low miR-106b expression.Conclusion:The lowly expressed miR-106b in nasopharyngeal carcinoma can promote the cell cycle progression and cell invasion in the lesion.
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