Effects of adjuvant bupleurum injection therapy in perioperative period of PCI on myocardial damage, oxidative stress response and apoptosis

摘要

Objective:To investigate the effects of adjuvant bupleurum injection therapy in perioperative period of PCI on myocardial damage, oxidative stress response and apoptosis.Methods:Patients with acute myocardial infarction who received PCI in Chengyue Community Health Center of Xisaishan District Huangshi City Hubei Province between June 2014 and February 2017 were selected as the research subjects and randomly divided into the bupleurum group who received adjuvant bupleurum injection therapy in perioperative period of PCI and the control group who received routine therapy in perioperative period of PCI. The myocardial damage indexes, oxidative stress indexes and apoptosis indexes in serum and peripheral blood were measured before treatment and 1 d and 3 d after treatment.Results: 1 d and 3 d after treatment, H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of both groups of patients were significantly lower than those before treatment and H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of bupleurum group were significantly lower than those of control group.Conclusion:Adjuvant bupleurum injection therapy in perioperative period of PCI can reduce the myocardial damage, oxidative stress response and apoptosis.