Correlation of serum Ang-2 level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure

摘要

Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure who were treated in the People's Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA I-II group and NYHA III-IV group according to cardiac function classification; healthy subjects who received physical examination during the same period were selected as the control group. The levels of Ang-2, neurohumor indexes and myocardial remodeling indexes in serum were determined. Results: Serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA I-II group and NYHA III-IV group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group; serum Ang-2, NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels of NYHA III-IV group were significantly higher than those of NYHA I-II group whereas TIMP4 level was significantly lower than that of NYHA I-II group. Serum NT-proBNP, Copeptin, ET-1, AT-II, ALD, FGF23, TGFβ1, Gal-3, PICP and ICTP levels in chronic heart failure patients with high Ang-2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion:The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.