Influences of laparoscopic radical correction of oophoroma combined with chemotherapy on tumor related factors and immunologic function levels

摘要

Objective: To study the influence of laparoscopic radical correction of oophoroma combined with chemotherapy on Tumor related factors and immunologic function levels. Methods:Retrospective analyses the 95 cases of ovarian cancer in our hospital from January 2013 to September 2017, which were divided into the control group and the observation group. The patients in the observation group underwent laparoscopic ovarian cancer radical surgery, the control group underwent open radical resection of ovarian cancer, two patients were combined with TP chemotherapy, the levels of serum MMP-9, HE4, YKL-40, EPO, PRL, TSGF and T lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) in two groups before and after treatment were detected and compared. Results: (1) Before treatment, there was no statistical difference between the levels of serum MMP-9, HE4, YKL-40, EPO, PRL, TSGF in the two groups; After treatment, the levels of serum MMP-9, HE4, YKL-40, EPO, PRL, TSGF in the control group were statistically significant compared with those before treatment in the same group, and the differences were statistically significant between the two groups. (2) Before treatment, there was no statistical difference between the levels of serum T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) in the two groups; After treatment, the differences of serum CD3+, CD4+, CD8+, CD4+/CD8+ were statistically significant compared with those before treatment in the same group, but the differences were not statistically significant between the two groups. Conclusion: Chemotherapy in patients with ovarian cancer TP in laparoscopic radical resection after, can not only significantly improve the patient's serum MMP-9, HE4, YKL-40, EPO, PRL, TSGF level. Moreover, compared with the simple operation, this method does not significantly affect the T lymphocyte subsets of the patients, and is worthy of clinical application.