Correlation of late-pregnancy serum 25-OH-VitD3 content with maternal endothelial injury and placental apoptosis

摘要

Objective: To study the correlation of late-pregnancy serum 25-OH-VitD3 content with maternal endothelial injury and placental apoptosis in pregnant women with preeclampsia (PE). Methods: PE pregnant women and healthy pregnant women who gave birth in the First People's Hospital of Yichang between June 2014 and February 2017 were selected as PE group and control group respectively. At 32 weeks of gestation and before delivery, the serum was collected respectively to determine the contents of 25-OH-VitD3 and endothelial lesion markers; after delivery, the placenta was collected to determine the expression of apoptosis molecules. Results: 25-OH-VitD3 contents in serum as well as XIAP and Survivin mRNA expression in placental tissue of PE group were significantly lower than those of control group while sEng, sFlt-1, IFI16 and tTG contents in serum as well as AP-2 , Smac and PTEN mRNA expression in placental tissue were significantly higher than those of control group; sEng, sFlt-1, IFI16 and tTG contents in serum as well as AP-2 , Smac and PTEN mRNA expression in placental tissue of PE pregnant women with low 25-OH-VitD3 content were significantly higher than those of PE pregnant women with high 25-OH-VitD3 content while XIAP and Survivin mRNA expression were significantly lower than those of PE pregnant women with high 25-OH-VitD3 content. Conclusions: The decline of late-pregnancy serum 25-OH-VitD3 content can aggravate the maternal endothelial injury and placental apoptosis in pregnant women with PE.