益气化痰活血法对血脂正常的高血压患者血管内皮功能的影响

摘要

目的:探讨益气化痰活血法对血脂正常的原发性高血压(Essential Hypertension,EH)患者血管内皮功能的影响.方法:218例EH患者按1:1随机分为对照组和试验组.前者给予常规西医治疗,后者在常规治疗基础上加用益气化痰活血法.治疗30d,比较两组的临床效果、内皮依赖性血管舒张功能(Flow-mediated Vasodilation,FMD)和收缩压.结果:疗程结束时,试验组总有效率显著高于对照组(97.25％ VS 86.24％,P＜0.05);试验组FMD显著高于对照组[(8.17±0.85)％ VS(6.26±0.74)％,P＜0.05];试验组SBP明显低于对照组[(128.64±17.35) VS(134.72-19.57),P＜0.05].结论:在常规西医治疗基础上加用益气化痰活血法能显著提高血脂正常EH患者的临床疗效,改善FMD和降低SBP.%Objective:To investigate the effect of promoting circulation of Qi and blood and dispersing phlegm on vascular endothelial function of essential hypertension patients without dyslipidemia.Method:218 cases of EH were evenly and randomly divided into two groups:a control group and a treatment group.The former group was treated with conventional western medicine,while the control group was added with the method of promoting circulation of Qi and blood and dispersing phlegm additionally.Mter 30 days,the total effective rate,flow-mediated vasodilation (FMD) and SBP were compared.Results:After the treatment,the total effective rate and FMD of the treatment group were significantly higher than those of the control group (97.25％ VS 86.24％,P ＜0.05).The FMD of the treatment was obviously higher than that of the control group [(8.17 ± 0.85) ％ VS (6.26 ± 0.74) ％,P ＜ 0.05];SBP was statistically lower in the treatment group than that in the control group [(128.64 ± 17.35) VS (134.72 ± 19.57),P ＜ 0.05].Conclusion:The convertional treatment added with the method of promoting circulation of Qi and blood and dispersing phlegm can effectively improve the vascular endothelial function of EH patients without dyslipidemia.It can also improve FMD and lower SBP.