一种新型三元体系磷酸钙骨水泥的制备与性能优化

摘要

制备了一种新型磷酸氢钙-部分结晶磷酸钙-磷酸四钙三元体系骨水泥,采用正交试验优化骨水泥组分以提高材料的性能。通过力学性能测试、X射线衍射分析、扫描电镜观察以及反应过程水化放热测定,对比研究了所制备的三元体系骨水泥材料的水化过程和物相组成。结果表明所添加活性磷酸四钙参与水化反应较慢,延长了骨水泥的凝结时间,拓展了后期水化效应,使得反应后期水化进程得以延续,硬化体更加密实,孔隙率降低,抗压强度增加50%;同时反应放热峰值显著降低40%,水化过程总放热量基本不变,有利于骨水泥在临床应用。%Reinforced calcium phosphate cement（CPC） composed of three compartments was prepared by orthogonal test to improve the properties in this study.The effects of tetracalcium phosphate on the mechanical properties,setting time,phase evolution,microstructure,and exothermal behavior of CPC were systematically investigated.The results demonstrated that with the tetracalcium phosphate reacting lowly,the compress strength of CPC was enhanced remarkably.New content obviously increased the setting time,reduced the porosity and enhanced the compressive strength of CPC by about 50%,the exothermal peak during reaction dropped by 40% while cumulative heat liberation maintained constant.This ternary CPC system should be a promising material for bone repair and bone reconstruction.