嵌段离聚体包覆DCOIT纳米胶囊的合成、表征及其释放特性的研究

摘要

以 PEG/IPDI/DMPA 为原料,通过溶液聚合法,获得了嵌段离聚体溶液(溶剂为 N,N-二甲基甲酰胺),然后在水相界面上对疏水功能性有机分子DCOIT进行自组装包覆制备DCOIT纳米胶囊。实验最终通过FT-IR、表面张力测试表征了嵌段离聚体的结构及性能,粒径分布和冷冻切片 TEM和紫外-可见分光光度计对DCOIT纳米胶囊的形貌和释放特性进行了研究。研究结果表明,实验制备出了预期结构的聚氨酯嵌段离聚体,并形成了 DCOIT 纳米胶囊；DCOIT纳米胶囊的释放特性表现为,当壁芯比在1∶1至2∶1之间变化时,纳米胶囊都在释放初期速率较快,然后经历一个减速期,随后速率再次增加；且随着壁芯比的减小,DCOIT 纳米胶囊的减速期越来越短。最后,对DCOIT 纳米胶囊的释放机理进行了初步探讨。%Self-assembly coated DCOIT nanocasules were synthesized by block ionomer solution,in which the solution was prepared by solution polymerization reaction using PEG/IPDI/DMPA (N,N-dimethylformamide was the solvent).The physicochemical properties of the block ionomer synthesized and the particle size,mor-phology and optical properties of the DCOIT nanocasules prepared were characterized with particle size analy-zer,transmission electron microscopy (TEM)and UV-Vis spectrometer.The results of this study showed that the block polyurethane and DCOIT nanocasules were prepared successfully.As the ratio of wall/core varied from 1∶1 to 2∶1 ,the release rate of the nanocapsules was fast at first,and then experienced a deceleration stage,after that,it increased sharply.The deceleration stage became shorter as the ratio decrease.Finally,the release mechanism of DCOIT nanocapsules was discussed.