首页> 中文期刊> 《东华大学学报:英文版》 >PREPARATION AND PROPERTIES OF MAGNETICALLY RESPONSIVE MICROCAPSULES OF THE DRUG FOR INJECTION USE

PREPARATION AND PROPERTIES OF MAGNETICALLY RESPONSIVE MICROCAPSULES OF THE DRUG FOR INJECTION USE

         

摘要

Microcapsules consisting of human serum albumin, magnetite and a prototype drug (5-fluroouracil) are obtained from emulsion by heat-stabilization. The most probable diametre of the magnet-sensitive microcapsules is 0.15 pm. The microcapsules satisfy the requirement of the magnetic carrier of drugs for the use of injection from theview points of size and shape. Flowing in an aqueous suspension, the microcapsules can be retained easily by the control of a magnetic field. The drug can be released gradually from the microcapsules when they are in physiological saline. The microcapsules prepared at the stabilization temperature of 200C have the least variable of permeation property. A structure model of the microcapsules has been proposed.

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