Fabrication and Drug Release Property of Silk Fibroin-Based Weft-Knitted Stents

摘要

This paper was to develop a weft-knitted stent coated by a drug-loaded electro-spun fibrous membrane and then investigate its morphology, mechanical properties and in vitro drug release property. This work was started by weft-knitting of an inner layer of such stent using polydioxanone( PDO) and silkfilament.Subsequently,5-fluorouracil( 5-FU) and curcumin( CUR) ioaded silk fibroin( SF) membranes were coated on the surface of the weftknitted stent using electro-spinning technique to endow the drug delivery function of the stent. The results show that the radial compression strength and circumferential expanding strength can reach above( 9. 1 ± 0. 4) cN/cm^2 and( 205. 0 ± 0. 2) c N/mm,respectively. The drug releasing behaviors can be sustained for 400 h. It is concluded that the stents have potential application as anintestinal stent in the future.