p53、C-erbB-2、VEGF-C和nm23在乳腺癌中的表达及临床意义

摘要

To study the expression and clinical significance of p53, C - erbB -2, VEGF ?C and nm23 in breast cancer. [Methods] The expression of p53, C - erbB -2, VEGF - C and nm23 were examined in 100 cases of breast cancer and adjacent normal breast tissue without chemotherapy by using SP immunohistochemical technique. [ Results] In 100 cases of breast cancer and adjacent normal breast tissue, the positive rate of p53, C - erbB - 2, VEGF - C and nm23 were 86. 0% and 30. 0% , 76. 7% and 25. 0% , 80. 0% and 20. 0% , 30. 0% and 90. 0% , respectively. There were significant difference in the positive rates of p53 and C - erbB - 2 in different lymphatic metastasis, clinical stages and histological grade ( P < 0.05 ) ; The expression of VEGF - C was significantly related with lymphatic metastasis, tumor sizes and histological grade (P<0.05) ; It showed significant correlations of the positive rate of nm23 in lymphatic metastasis ( P <0.05). [ Conclusion] The expression of p53, C - erbB - 2, VEGF - C and nm23 were positively related to the metastasis and prognosis of breast cancer, the combined detection of p53, C - erbB - 2, VEGF - C and nm23 is valuable to predicting prognosis and guiding therapy of breast cancer.%[目的]探讨p53、C- erbB -2、VEGF -C和nm23在乳腺癌中的表达及临床意义.[方法]应用免疫组化SP法检测100例乳腺癌组织及其癌旁正常乳腺组织活性标本中p53、C - erbB -2、VEGF-C和nm23蛋白表达情况.[结果]乳腺癌组织和癌旁正常组织中p53、C- erbB -2、VEGF-C和nm23蛋白阳性表达率分别为86.0％和30.0％、76.7％和25.0％、80.0％和20.0％,30.0％和90.0％；p53和C- erbB -2蛋白阳性表达在有无淋巴结转移、不同临床分期和癌分化程度上差异有显著性意义(P ＜0.05)；VEGF -C蛋白阳性表达在有无淋巴结转移、肿瘤大小和癌分化程度上差异有显著性意义(P ＜0.05)；nm23蛋白阳性表达在有无淋巴结转移上差异有显著性意义(P＜0.05).[结论] p53、C- erbB -2和VEGF-C阳性表达是乳腺癌患者预后差的指标,nm23表达则提示乳腺癌患者预后较好,联合检测p53、C- erbB -2、VEGF-C和nm23有助于乳腺癌患者的治疗和预后判断.