济川凿岩散联合 FolFox4方案治疗晚期结直肠癌疗效观察

摘要

目的：观察济川凿岩散联合 FolFox4方案治疗晚期结直肠癌的临床疗效。方法回顾性分析24例晚期结直肠癌患者化疗的临床资料。化疗方案均采用 FolFox4方案,于化疗期间和化疗后两周配合服用济川凿岩散,观察近期疗效、毒副反应及生存质量变化。结果近期疗效中 CR3例,PR6例,SD12例,PD3例,总有效率(CR+PR)9例,占37.5%；而受益率(CR+PR+SD)21例,占87.5%；毒副反应以恶心、呕吐、腹泻为主,多为轻至中度,骨髓抑制为轻至中度,患者耐受性良好。生存质量上,治疗前后比较卡氏评分有所增加,但卡氏评分增加<10分,因此生存质量稳定。结论济川凿岩散联合 FolFox4方案治疗晚期结直肠癌,对部分失去手术机会或年老体衰无法承受手术的患者,通过保守治疗,可减毒增效,并在一定程度上提高生存质量。%Objective To evaluate the efficacy of Jichuan Zaoran San combined with FOLFOX4 chemother-apy for the treatment of advanced colorectal cancer.Methods Twenty four patients of advanced-stage color-ectal cancer patients were aretrospective analyzed,all of whom were treated using FOLFOX4 chemothera-py regimen.Herbs prescribed complying with the method of Jichuan Zaoran San were applied during chemotherapy and for 2 weeks after completion of chemotherapy.Recent treatment effects,toxic side-effects and changes in quality of life were observed.Results Of the recent treatment effects,3 samples were CR,6 samples were PR,12 samples were SD,3 samples were PD,9 samples were CR+PR,which constituted 37.5%.21 samples were CR+PR+SD,which constituted 87.5%.Toxic side-effects mainly included nausea,vomiting and diarrhea,most of which were light to medium degree.Bonem arrow sup-pression effects were mostly light to medium degree.In general,all patients had good tolerance.In as-sessment of patients'quality of life,Karnofsky score after treatments decreased as compared to that before treatments.Since the decrease in Karnofsky score was<10,the quality of life was considered as stable. Conclusion Applying the method of Jichuan Zaoran San combined with FOLFOX4 chemotherapy in treat-ment of advanced-stage colorectal cancer,which may enable patients who lost the opportunity of operation or originally unable to tolerate chemotherapy due to old age to regain treatment opportunities,might re-duce toxicity and enhance treatment effects,as well as elevate patients'quality of life.