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首页> 中文期刊> 《临床与转化肝病杂志（英文版）》 >Curing Hepatitis C in Liver Transplant Recipients Is Associated with Changes in Immunosuppressant Use

Curing Hepatitis C in Liver Transplant Recipients Is Associated with Changes in Immunosuppressant Use

         
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摘要

Background and Aims:All-oral interlferon-free antivirals are highly effective in treating recurrent hepatitis C (HCV) infection in liver transplant (LT) recipients.The aim of the study was to assess immunosuppression needs after achieving a sustained viral response (SVR).Methods:We compared immunosuppression needs before and after achieving a SVR in adult LT recipients treated for recurrent HCV infection with alloral direct acting agents.Results:We identified 52 liver LT treated recipients who achieved a SVR.The median (25th and 75th percentile interquartile range [IQR]) age was 62 years (57.75,65).Most recipients received tacrolimus (TAC) for their immunosuppressant regimen.After achieving SVR,there was no statistically significant difference in daily dose of TAC unadjusted per weight (p > 0.05).However,there was a statistically significant decrease in daily dose of TAC adjusted per weight,serum levels of TAC,and the product of glomerular filtration rate and TAC.No statistically significant differences in cyclosporine unadjusted/adjusted per weight daily dose or serum levels were noted.Conclusions:Immunosuppression needs were increased for those patients treated with TAC but not cyclosporine.LT recipients prescribed TAC require close monitoring after treatment completion to avoid potential risk of acute rejection.

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  • 来源
    《临床与转化肝病杂志（英文版）》 |2016年第1期|P.32-38|共7页
  • 作者

    Sammy Saab; Justin Rheem; Melissa Jimenez; Sherona Bau; Gina Choi; Francisco Durazo; Mohammed El Kabany; Steven Han; Alexander Farid; Naadir Jamal; Jonathan Grotts; David Elashoff; Ronald W.Busuttil;

  • 作者单位

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

    Departments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartment of Medicine at Harbor-University of California at Los Angeles Medical Center Torrance California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Surgery at the University of California at Los Angeles Los Angeles California USADepartments of Medicine at the University of California at Los Angeles Los Angeles California USADepartment of Biostatistics at the University of California at Los Angeles Los Angeles California USA;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    Liver transplantation; Immunosuppressant; Hepatitis C; Direct acting agents;

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