N末端B型利钠肽原在急诊老年呼吸困难患者鉴别中的应用意义

摘要

目的 研究血浆N末端B型利钠肽原(NT-proBNP)水平对急诊老年呼吸困难患者鉴别诊断的临床意义.方法 急诊科就诊老年呼吸困难患者182例,分为心源性呼吸困难和肺源性呼吸困难两组.分别检查血浆NT-proBNP含量,并给予心脏超声检查,比较两组患者NT-proBNP含量和左室射血分数的区别;并对心源性呼吸困难组NT-proBNP含量与左室射血分数进行相关分析.结果 肺源性呼吸困难组NT-proBNP含量为108.5±25.7 pg/ml,心源性呼吸困难组NT-proBNP含量为945.1±143.8 pg/ml(P=0.001);相关分析显示老年心源性呼吸困难组NT-proBNP与左室射血分数呈负相关关系(r=-0.62,P<0.01).结论 NT-proBNP对老年呼吸困难患者鉴别诊断具有一定临床意义.%Objective To study clinical significance of ami no-terminal poition of brain natriuretic peptide levels in elderly pa tients emergency with dyspnea. Methods 182 elderly patients with dyspnea were divided into cardiogenic dyspnea and pulmonary dysp nea group. Plasma NT-proBNP content and cardiac ultrasound dopplei were examined and compared between the 2 groups, then the con nection between the content of NT-proBNP and left ventricular ejection fraction correlation was analyzed. Results It contained 108. 5 ?25. 7 pg/ml NT-proBNP in the pulmonary dyspnea group and 945. 1 ?43.8 pg/ml in the rardiogenir dyspnea group ( P = 0. 001 ). Cor relation analysis showed that NT-proBNP and left ventricular ejection fraction was negatively correlated in the elderly cardiogenic dyspnea group ( r = -0.62,P<0.01 ). Conclusion NT-proBNP has.certain clinical significance for the differential diagnosis in elder patients with dyspnea.