C反应蛋白检测在慢性阻塞性肺疾病的临床意义及与肺功能相关性研究

摘要

Objective To investigate the changes and clinical significance of serum C-reactive protein( CRP) in the patients with the acute exacerbation and remission of chronic obstructive pulmonary disease(COPD) .meanwhile to reasch the relationship between CRP and pulmonary function. Methods To select 46 patients and detect the changes of CRP level, leukocyte counts ( WBC ) , neutrophil counts (N) ,Xiechen(ESR) ,pulmonary function FEV, % before and after treatment. To compare the changes of this index. Results Patients with COPD aggravating period was higher than other lob CRP index. The after-treatment significant improvement ( P < 0. 01 ). There are negative correlation between CRP level and pulmonary function FEV, % before and after treatment, but there is no significance in statistics ( P > 0. 05 ) . Conclusion The serum CRP level is a sensitive index in COPD patients with acute exacerbations, and it is also a good index to judge the early therapeutic efficacy in COPD patients with acute exacerbations.%目的 探讨COPD患者急性加重期与稳定期血清C反应蛋白(CRP)含量变化的临床价值,及其与肺功能的相关性.方法 选择AECOPD患者46例,比较其治疗前后CRP水平及白细胞总数(WBC)、中性粒细胞计数(N)、血沉(ESR)和肺功能FEV1％.结果 AECOPD患者CRP阳性率高于其他指标,治疗后明显下降,具有统计学差异(P＜0.01).治疗前后CRP与FEV1％均呈负相关,但无统计学意义(P＞0.05).结论 CRP可作为AECOPD的敏感指标,及治疗效果的评价指标.