45例老年肺癌合并静脉血栓栓塞症患者的临床观察

摘要

Objective To analyze the rliniral risk factors of elderly patients with lung ranrer romplirated with venous thromboembolism ( VTE ) and to learn more about it. Methods The rliniral data of 1026 patients with lung ranrer, whose pathology of VTE was roniirmed by CT, colorful Doppler ultrasound and pulmonaiy arteriography, were retrospectively analyzed. The clinical factors included age, gender, pathological type, platelet count, D-dimer, inteileukin-1 ( IL-1 ) and tumor necrosis factor ( TNF ). Results Of the 1026 patients, 45 patients ( 4. 39% ) were confirmed with VTE. The incidences of VTE in patients with normal levels of platelet count, D-dimer, IL-1 and TNF were 3.71% , 0. 32% , 2. 43% and 3. 26% respectively. Whereas, the incidences in patients with increased levels of those measurements were 6. 27% , 19. 92% , 10.31% and 7.81% respectively. The differences between two groups were significant ( P < 0. 05 ). Logistic multi-variant regression analysis revealed that the clinical risk factors of VTE were the high levels of IL-1 , D-dimer and TNF ( P <0. 05 ). Conclusion The risk factor of VTE is the increase of IL-1 , D-dimer and TNF in patients with lung cancer.%目的 分析老年肺癌合并静脉血栓栓塞症(VTE)患者的临床危险因素.方法 选取我院收治的1026例经确诊的肺癌患者为研究对象,并分析以下相关因素:患者年龄、性别、病理类型、治疗前血小板计数、白细胞介素1 (IL-1)、D-二聚体、肿瘤坏死因子(TNF).结果 上述肺癌患者中,45 例(4.39%)患者并发静脉血栓栓塞.相关因素方面,血小板计数、IL-1、D-二聚体、TNF水平正常的患者VTE发生率分别为3.71%、0.32%、2.43%和3.26%,而上述水平升高的患者VTE发生率分别为6.27%、19.92%、10.31%和7.81%,差异明显(P＜0.05).Logistic分析,IL-1、D-二聚体、TNF水平升高是肺癌患者并发静脉血栓栓塞症的临床危险因素(P＜0.05).结论 肺癌患者发生VTE的危险因素为IL-1、D-二聚体和TNF.