WASP 结合蛋白在非小细胞肺癌中的表达及临床病理意义

摘要

目的：探讨 WASP 结合蛋白(WASP-interacting protein,WIP)在非小细胞肺癌组织中的表达及与非小细胞肺癌临床病理特征之间的关系。方法采用免疫组化 SP 二步法,检测 WIP 在石蜡固定的110例非小细胞肺癌组织和70例癌旁组织中的表达。结果非小细胞肺癌组织中 WIP 的表达明显高于癌旁组织中的表达(P <0．01),并与肿瘤的分化程度、TNM 分期以及淋巴结转移相关(P <0．05或 P <0．01)。 WIP 高表达组的3年生存率(32．14%)低于低表达组(71．43%)。 WIP 高表达及淋巴结转移是是影响非小细胞肺癌患者独立的预后因素。结论 WIP 在非小细胞肺癌中异常高表达,可能参与并促进肿瘤的恶性进程,检测其表达情况会对评估非小细胞肺癌患者是否有淋巴结侵犯及预后起一定的提示作用。%Objective To investigate the expression of WASP-interacting protein (WIP) in non-small cell lung cancer (NSCLC) and its clinical significance. Methods The expression of WIP was detected in 110 cases of paraffin-embedded NSCLC tissues and 70 cases of adjacent normal lung tissue by immunohistochemistry. Results The expression of WIP in NSCLC were distinctly higher than that in the control group. The expression of WIP in NSCLC was correlated with differentiation, TNM stage and lymph node metastasis (P < 0. 05 or P < 0. 01). The 3-year survival rate of patients with Cdc42 high expression (32. 14% ) were lower in patients than those with low ex-pression(71. 43% ). The high expression of WIP and lymph node metastasis were independent factors affecting pa-tient prognosis with NSCLC. Conclusion The high expression of WIP in NSCLC tissues may involve and promote the malignant progress of tumor, which makes the detection of WIP in NSCLC tissues can evaluate the lymph node metastasis and prognosis.