目的 探讨炎症因子血清肿瘤坏死因子、白介素-6、8、10在婴幼儿哮喘中的发病机制.方法 选择在我院就诊的66例婴幼儿哮喘患儿,按年龄分为婴儿组和幼儿组各33例,并选择在我院健康体检的无哮喘儿童32例为对照组,所有患儿均于就诊的次日行肿瘤坏死因子、血清白介素-6、8、10测试.结果 哮喘组肿瘤坏死因子、血清白介素-6、8浓度高于非哮喘组(P<0.05),血清白介素-10浓度低于非哮喘组(P<0.05).结论 肿瘤坏死因子、血清白介素-6、8、10在哮喘的气道的炎症反应中有重要作用,可为婴幼儿哮喘的诊疗管理提供参考依据.%Objective To investigate the pathogenesis of inflammatory factors in serum tumor necrosis factor, interleukin-6, interleukin-8 and interleukin-10 in infants with asthma.Methods 66 infants with asthma were evenly divided into the infant group and the young group according to their age, and 32 children without asthma were selected as the control group.All children were given the detection of serum tumor necrosis factor, interleukin-6, interleukin-8 and interleukin-10 at the second day.Results The levels of serum tumor necrosis factor, interleukin-6 and interleukin-8 in the asthmatic group were higher than those in the control group (P<0.05), and serum interleukin-10 was lower than that of in the control group (P<0.05).Conclusion Tumor necrosis factor, serum interleu-kin-6, interleukin-8 and interleukin-10 in the airway inflammation of asthma play an important role in treatment of infants and young children, which can provide a basis for diagnosis and treatment.
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